O39 Lack of association of anti-ribosomal P protein antibodies in neuropsychiatric SLE

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Lack of Association between Anti-Ribosomal-P Antibody and Chemokines in Neuropsychiatric Syndromes of Systemic Lupus Erythematosus

Anti-ribosomal P protein antibody (anti-P) in cerebral spinal fluids (CSF) has been reported to associate with NPSLE and IgG anti-P in CSF was suggested to be a useful marker for the diagnosis of neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE). There is growing evidence that chemokines, such as MCP-1/CCL2 and IP10/CXCL10 are involved in the pathogenesis of NPSLE. To study the...

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Restricted specificity of anti-ribosomal P antibodies to SLE patients in Israel.

OBJECTIVE Anti-ribosomal P antibodies (aRib-P Ab) are highly specific for systemic lupus erythematosus (SLE), but their correlatation with disease activity and manifestations including renal, hepatic and central nervous system (CNS) involvement is still controversial. The aim of our study was to evaluate the prevalence of aRib-P Ab and their correlation with clinical manifestations and anti-dsD...

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Sense of smell, anti-ribosomal p antibodies and neuropsychiatric manifestations in childhood systemic lupus erythematosus

Introduction Neuropsychiatric involvement in cSLE has a prevalence ranging from 20 to 95% and results in significant morbidity and mortality. Multiple autoantibodies have been reported in association with NPSLE. Anti-P seem to be highly specific for SLE and might also be a marker for SLE disease activity. In SLE population the prevalence of anti-P varies from 6% a 46% depending on ethnicity, ag...

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Association of cerebrospinal fluid anti-ribosomal P protein antibodies with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus

We explored the relationship of antibodies to the whole ribosomal P proteins (P0, P1, and P2) in cerebrospinal fluid (CSF) with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus (SLE). CSF samples were obtained from 71 SLE patients (52 patients with diffuse psychiatric/neuropsychological syndromes [diffuse NP-SLE] and 19 patients with neurological syndromes or per...

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ژورنال

عنوان ژورنال: Indian Journal of Rheumatology

سال: 2008

ISSN: 0973-3698

DOI: 10.1016/s0973-3698(10)60413-x